View Indications

WHAT IS OTREXUP? (INDICATIONS)

OTREXUP is a single-dose auto-injector containing a prescription medicine, methotrexate.
Methotrexate is used to:

  • Treat certain adults with severe, active rheumatoid arthritis (RA), and children with active polyarticular juvenile idiopathic arthritis (pJIA), after treatment with other medicines including non-steroidal anti-inflammatory drugs (NSAIDs) have been used and did not work well.
  • Control the symptoms of severe, resistant, disabling psoriasis in adults when other types of treatment have been used and did not work well.

OTREXUP should not be used for the treatment of cancer.
OTREXUP should not be used for the treatment of children with psoriasis.

For U.S. Residents Only

What is OTREXUP? (Indications)

OTREXUP is a single-dose auto-injector containing a prescription medicine, methotrexate.1
Methotrexate is used to1:

  • Treat certain adults with severe, active rheumatoid arthritis (RA), and children with active polyarticular juvenile idiopathic arthritis (pJIA), after treatment with other medicines including non-steroidal anti-inflammatory drugs (NSAIDs) have been used and did not work well.
  • Control the symptoms of severe, resistant, disabling psoriasis in adults when other types of treatment have been used and did not work well.

OTREXUP should not be used for the treatment of cancer.1
OTREXUP should not be used for the treatment of children with psoriasis.1

  • RA is a type of autoimmune disease, where the body’s own immune system mistakenly attacks healthy cells instead of unhealthy one2
  • RA affects approximately 1.3 million Americans. About 75% of RA patients are women2,3
  • RA generally begins between the ages of 30 and 50. However, RA can start at any age2
  • RA causes pain, swelling, and reduced range of motion in the wrist and small joints of the hands and feet, but it can also affect the shoulders and knees2
Female body diagram indicating joints that could be affected by RA
Female body diagram indicating joints that could be affected by RA

  • Juvenile idiopathic arthritis (JIA) is the most common arthritis in children under the age of 16. It affects almost 1 in 1000 children in the US6
  • JIA can cause joint pain, swelling, and stiffness. Some children have symptoms for only a few months, whereas others can have symptoms for years7
  • Most children with JIA have the polyarticular form (pJIA), which means having arthritis in 5 or more joints8

  • Psoriasis is a chronic skin disease9
  • Psoriasis can cause rashes with itchy, scaly patches, most commonly on the knees, elbows, trunk, and scalp9
  • According to the National Psoriasis Foundation, approximately 7.5 million Americans have psoriasis10

Meet the Otrexup autoinjector

Otrexup® injection with detached safety cap highlighting its featuresOtrexup® injection with detached safety cap highlighting its featurespinch to zoom

Otrexup autoinjection can be an easy-to-use option

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In a study of 101 adult RA patients, 98% agreed that Otrexup was easy to use.11

In adult RA patients with moderate to severe functional limitations, most of them (80.2%) had previous experience with SC (under the skin) administration; 31 had used an autoinjector, 24 had used a pen device, and 53 had used a needle and syringe with a vial. Approximately 77% were receiving oral tablets of methotrexate at enrollment.11

No pain icon

Patients experienced no or minimal pain.11

In a clinical study of 101 adult RA patients, 55 and 74 patients reported no or minimal administration-site pain on Day 1 and Day 2, respectively.11

Close-up illustration of Otrexup® auto-injector with cap

Otrexup is designed so the needle is not visible.11

Eye icon demonstrating partial visibility

With Otrexup, less of the bright yellow methotrexate is visible.

Small medication window, minimal view of yellow methotrexate.

Otrexup general steps for administration1

Before giving the injection, see patient instructions for use for complete administration instructions.

Step 1

Step 1 of Otrexup Administration shows a person removing the cap marked as 1 by twisting it

Remove cap

  • Twist cap marked 1 to remove. This will break the seal
  • Do not replace the cap after it has been removed
  • After the cap is removed, Otrexup must be used or disposed of safely

Step 2

Step 2 of Otrexup Administration shows a person removing the safety clip marked as 2 by flipping it

Remove the safety clip

  • Flip the safety clip marked 2

Step 3

Step 2 of Otrexup Administration shows a person injecting the Otrexup injection into the thigh or abdomen

Administer Otrexup in the thigh or abdomen

  • Place the needle end of Otrexup flat against thigh or stomach at a 90° and firmly push device against the injection site until fully depressed. You will hear a click, then hold for 3 seconds
  • Do not inject Otrexup within 2 inches of the belly button (navel)
  • Do not inject Otrexup in the arms or any other areas of the body
  • You may notice a small amount of blood or liquid at the administration site, which is normal
  • Remove Otrexup from the site and press a cotton ball on the area for 10 seconds. Do not rub the area
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Going in for a checkup? Start a conversation with your doctor about Otrexup!

JIA, juvenile idiopathic arthritis; NSAIDs, non-steroidal anti-inflammatory drugs; pJIA, polyarticular juvenile idiopathic arthritis; RA, rheumatoid arthritis; SC, subcutaneous.

References:

1. Otrexup. Prescribing information. Antares Pharma Inc; 2019. 2. Rheumatoid Arthritis. American College of Rheumatology. Accessed September 26, 2022. https://rheumatology.org/patients/rheumatoid-arthritis. 3. Xu Y, Wu Q. Prevalence Trend and Disparities in Rheumatoid Arthritis among US Adults, 2005-2018. J Clin Med. 2021;10(15):3289. 4. Chung KC, Pushman AG. Current concepts in the management of the rheumatoid hand. J Hand Surg Am. 2011;36(4):736-747. 5. American Academy of Orthopedic Surgeons. Rheumatoid Arthritis of Foot and Ankle. OrthoInfo. Accessed September 26, 2022. https://orthoinfo.aaos.org/en/diseases--conditions/rheumatoid-arthritis-of-the-foot-and-ankle. 6. Wallace CA, Giannini EH, Spalding SJ, et al. Childhood Arthritis and Rheumatology Research Alliance. Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis. Arthritis Rheum. 2012;64(6):2012-2021. 7. Juvenile idiopathic arthritis. Mayo Clinic. Accessed September 26, 2022. https://www.mayoclinic.org/diseases-conditions/juvenile-idiopathic-arthritis/symptoms-causes/syc-20374082. 8. Ringold S, Weiss PF, Colbert RA, et al. Juvenile Idiopathic Arthritis Research Committee of the Childhood Arthritis and Rheumatology Research Alliance. Childhood Arthritis and Rheumatology Research Alliance consensus treatment plans for new-onset polyarticular juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2014;66(7):1063-1072. 9. Psoriasis. Mayo Clinic. Accessed September 26, 2022. https://www.mayoclinic.org/diseases-conditions/psoriasis/symptoms-causes/syc-20355840. 10. Armstrong AW, Mehta MD, Schupp CW, et al. Psoriasis Prevalence in Adults in the United States. JAMA Dermatol. 2021;157(8):940-946. 11. Freundlich B, Kivitz A, Jaffe JS. Nearly pain-free self-administration of subcutaneous methotrexate with an autoinjector: results of a phase 2 clinical trial in patients with rheumatoid arthritis who have functional limitations. J Clin Rheumatol. 2014;20(5):256-260.

IMPORTANT SAFETY INFORMATION AND INDICATIONS FOR OTREXUP®

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT OTREXUP?

OTREXUP can cause serious side effects that can lead to death, including:

  1. Organ system toxicity. People who use methotrexate for the treatment of cancer, psoriasis, or rheumatoid arthritis, have an increased risk of death from organ toxicity. Types of organ toxicity can include:

    • gastrointestinal
    • nerve
    • bone marrow
    • lung
    • liver
    • kidneys
    • immune system
    • skin

    Your doctor will do blood tests and other types of tests before you take and while you are taking OTREXUP to check for signs and symptoms of organ toxicity. Call your doctor right away if you have any of the following symptoms of organ toxicity:

    • vomiting
    • neck stiffness
    • diarrhea
    • paralysis
    • mouth sores
    • irritability
    • fever
    • sleepiness
    • confusion
    • problems with coordination
    • weakness
    • dry cough
    • temporary blindness
    • trouble breathing
    • seizures
    • severe skin rash
    • headache
    • back pain

  2. Women who are pregnant are at increased risk for death of the baby and birth defects. Women who are pregnant or who plan to become pregnant must not take OTREXUP. A pregnancy test should be performed before starting OTREXUP. Contraception should be used by both females and males while taking OTREXUP. Pregnancy should be avoided if either partner is receiving OTREXUP:

    • for a minimum of 3 months after treatment with OTREXUP for males.
    • during and for 6 months after treatment with OTREXUP for females.

WHAT IS OTREXUP? (INDICATIONS)

OTREXUP is a single-dose auto-injector containing a prescription medicine, methotrexate.

Methotrexate is used to:

  • Treat certain adults with severe, active rheumatoid arthritis (RA), and children with active polyarticular juvenile idiopathic arthritis (pJIA), after treatment with other medicines including non-steroidal anti-inflammatory drugs (NSAIDs) have been used and did not work well.
  • Control the symptoms of severe, resistant, disabling psoriasis in adults when other types of treatment have been used and did not work well.

OTREXUP should not be used for the treatment of cancer.

OTREXUP should not be used for the treatment of children with psoriasis.

WHO SHOULD NOT TAKE OTREXUP?

Do not use OTREXUP if you:

  • Are pregnant or planning to become pregnant. See “What is the most important information I should know about OTREXUP?”
  • Are breastfeeding; OTREXUP can pass into your breast milk and may harm your baby.
  • Have alcohol problems (alcoholism)
  • Have liver problems
  • Have problems fighting infection (immunodeficiency syndrome)
  • Have been told you have (or think you have) a blood disorder such as low levels of white blood cells, red blood cells (anemia), or platelets
  • Have had an allergy to methotrexate or any of the ingredients in OTREXUP. See the Prescribing Information for a list of ingredients in OTREXUP.

Talk to your doctor before taking this medicine if you have any of these conditions.

WHAT SHOULD I TELL MY HEALTHCARE PROVIDER BEFORE USING OTREXUP?

Before you take OTREXUP, tell your doctor if you have any other medical conditions.

Tell your doctor about all of the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements. OTREXUP may affect how other medicines work, and other medicines may affect how OTREXUP works causing side effects. Ask your doctor or pharmacist for a list of medicines if you are not sure.

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

HOW SHOULD I USE OTREXUP?

  • Read the Instructions for Use that come with OTREXUP.
  • Take OTREXUP exactly as your doctor tells you to take it.
  • Inject OTREXUP only 1 time each week. Do not take OTREXUP every day. Taking OTREXUP every day may cause death from toxicity.
  • Your doctor will show you or your caregiver how to inject OTREXUP. You should not inject OTREXUP until you have been trained on the right way to use it.
  • Check OTREXUP before you inject it. OTREXUP should be yellow in color and should not have any lumps or particles in it.
  • OTREXUP should be injected in the stomach (abdomen) or thigh.
  • Do not inject OTREXUP within 2 inches of the belly button (navel).
  • Do not inject OTREXUP in the arms or any other areas of the body.
  • Do not inject OTREXUP in areas where the skin is tender, bruised, red, scaly, hard, or has scars or stretch marks.
  • If you are not sure if OTREXUP was injected, or if you have a hard time giving the injection, do not inject another dose. Call your pharmacist or doctor right away.
  • If you inject too much OTREXUP, call your doctor or go to the nearest hospital emergency room right away.

WHAT SHOULD I AVOID WHILE USING OTREXUP?

  • Do not drink alcohol while taking OTREXUP. Drinking alcohol can increase your chances of getting serious side effects.
  • OTREXUP can cause dizziness and tiredness. Do not drive a car, operate machinery, or do anything that needs you to be alert until you know how OTREXUP affects you.
  • Certain vaccinations should be avoided while taking OTREXUP. Talk to your doctor before you or members of your household receive any vaccines.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF OTREXUP?

OTREXUP may cause serious side effects, including:

  • Fertility problems. Methotrexate, the active ingredient in OTREXUP, may affect your ability to have a baby. Males may have a decreased sperm count, and females may have changes to their menstrual cycle. This can happen while taking OTREXUP and for a short period of time after you stop.
  • Certain cancers. Some people who have taken methotrexate have had a certain type of cancer called Non-Hodgkin’s lymphoma and other tumors. Your doctor may tell you to stop taking OTREXUP if this happens.
  • Tissue and bone problems. Taking methotrexate while having radiation therapy may increase the risk of your tissue or bone not receiving enough blood. This may lead to death of the tissue or bone.

Common side effects of OTREXUP include:

  • nausea
  • headache
  • stomach pain
  • bronchitis
  • indigestion (dyspepsia)
  • low red, white, and platelet cell count
  • mouth sores
  • hair loss
  • rash
  • dizziness
  • stuffy or runny nose and sore throat
  • sensitivity to light
  • diarrhea
  • burning skin lesions
  • abnormal liver function tests
  • lung problems
  • vomiting

Tell your doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of OTREXUP. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information, including Boxed Warning and Patient Information, at www.otrexup.com/PI.

IMPORTANT SAFETY INFORMATION AND INDICATIONS FOR OTREXUP®

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT OTREXUP?

OTREXUP can cause serious side effects that can lead to death, including:

  1. Organ system toxicity. People who use methotrexate for the treatment of cancer, psoriasis, or rheumatoid arthritis, have an increased risk of death from organ toxicity. Types of organ toxicity can include:

    • gastrointestinal
    • nerve
    • bone marrow
    • lung
    • liver
    • kidneys
    • immune system
    • skin

    Your doctor will do blood tests and other types of tests before you take and while you are taking OTREXUP to check for signs and symptoms of organ toxicity. Call your doctor right away if you have any of the following symptoms of organ toxicity:

    • vomiting
    • neck stiffness
    • diarrhea
    • paralysis
    • mouth sores
    • irritability
    • fever
    • sleepiness
    • confusion
    • problems with coordination
    • weakness
    • dry cough
    • temporary blindness
    • trouble breathing
    • seizures
    • severe skin rash
    • headache
    • back pain

  2. Women who are pregnant are at increased risk for death of the baby and birth defects. Women who are pregnant or who plan to become pregnant must not take OTREXUP. A pregnancy test should be performed before starting OTREXUP. Contraception should be used by both females and males while taking OTREXUP. Pregnancy should be avoided if either partner is receiving OTREXUP:

    • for a minimum of 3 months after treatment with OTREXUP for males.
    • during and for 6 months after treatment with OTREXUP for females.

WHAT IS OTREXUP? (INDICATIONS)

OTREXUP is a single-dose auto-injector containing a prescription medicine, methotrexate.

Methotrexate is used to:

  • Treat certain adults with severe, active rheumatoid arthritis (RA), and children with active polyarticular juvenile idiopathic arthritis (pJIA), after treatment with other medicines including non-steroidal anti-inflammatory drugs (NSAIDs) have been used and did not work well.
  • Control the symptoms of severe, resistant, disabling psoriasis in adults when other types of treatment have been used and did not work well.

OTREXUP should not be used for the treatment of cancer.

OTREXUP should not be used for the treatment of children with psoriasis.

WHO SHOULD NOT TAKE OTREXUP?

Do not use OTREXUP if you:

  • Are pregnant or planning to become pregnant. See “What is the most important information I should know about OTREXUP?”
  • Are breastfeeding; OTREXUP can pass into your breast milk and may harm your baby.
  • Have alcohol problems (alcoholism)
  • Have liver problems
  • Have problems fighting infection (immunodeficiency syndrome)
  • Have been told you have (or think you have) a blood disorder such as low levels of white blood cells, red blood cells (anemia), or platelets
  • Have had an allergy to methotrexate or any of the ingredients in OTREXUP. See the Prescribing Information for a list of ingredients in OTREXUP.

Talk to your doctor before taking this medicine if you have any of these conditions.

WHAT SHOULD I TELL MY HEALTHCARE PROVIDER BEFORE USING OTREXUP?

Before you take OTREXUP, tell your doctor if you have any other medical conditions.

Tell your doctor about all of the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements. OTREXUP may affect how other medicines work, and other medicines may affect how OTREXUP works causing side effects. Ask your doctor or pharmacist for a list of medicines if you are not sure.

Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

HOW SHOULD I USE OTREXUP?

  • Read the Instructions for Use that come with OTREXUP.
  • Take OTREXUP exactly as your doctor tells you to take it.
  • Inject OTREXUP only 1 time each week. Do not take OTREXUP every day. Taking OTREXUP every day may cause death from toxicity.
  • Your doctor will show you or your caregiver how to inject OTREXUP. You should not inject OTREXUP until you have been trained on the right way to use it.
  • Check OTREXUP before you inject it. OTREXUP should be yellow in color and should not have any lumps or particles in it.
  • OTREXUP should be injected in the stomach (abdomen) or thigh.
  • Do not inject OTREXUP within 2 inches of the belly button (navel).
  • Do not inject OTREXUP in the arms or any other areas of the body.
  • Do not inject OTREXUP in areas where the skin is tender, bruised, red, scaly, hard, or has scars or stretch marks.
  • If you are not sure if OTREXUP was injected, or if you have a hard time giving the injection, do not inject another dose. Call your pharmacist or doctor right away.
  • If you inject too much OTREXUP, call your doctor or go to the nearest hospital emergency room right away.

WHAT SHOULD I AVOID WHILE USING OTREXUP?

  • Do not drink alcohol while taking OTREXUP. Drinking alcohol can increase your chances of getting serious side effects.
  • OTREXUP can cause dizziness and tiredness. Do not drive a car, operate machinery, or do anything that needs you to be alert until you know how OTREXUP affects you.
  • Certain vaccinations should be avoided while taking OTREXUP. Talk to your doctor before you or members of your household receive any vaccines.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF OTREXUP?

OTREXUP may cause serious side effects, including:

  • Fertility problems. Methotrexate, the active ingredient in OTREXUP, may affect your ability to have a baby. Males may have a decreased sperm count, and females may have changes to their menstrual cycle. This can happen while taking OTREXUP and for a short period of time after you stop.
  • Certain cancers. Some people who have taken methotrexate have had a certain type of cancer called Non-Hodgkin’s lymphoma and other tumors. Your doctor may tell you to stop taking OTREXUP if this happens.
  • Tissue and bone problems. Taking methotrexate while having radiation therapy may increase the risk of your tissue or bone not receiving enough blood. This may lead to death of the tissue or bone.

Common side effects of OTREXUP include:

  • nausea
  • headache
  • stomach pain
  • bronchitis
  • indigestion (dyspepsia)
  • low red, white, and platelet cell count
  • mouth sores
  • hair loss
  • rash
  • dizziness
  • stuffy or runny nose and sore throat
  • sensitivity to light
  • diarrhea
  • burning skin lesions
  • abnormal liver function tests
  • lung problems
  • vomiting

Tell your doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of OTREXUP. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information, including Boxed Warning and Patient Information, at www.otrexup.com/PI.

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